| Pair Name | Alantolactone, Oxaliplatin | ||
| Phytochemical Name | Alantolactone (PubChem CID: 72724 ) | ||
| Anticancer drug Name | Oxaliplatin (PubChem CID: 9887053 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Alantolactone, Oxaliplatin | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->ROS accumulation | |||
| Gene Regulation | Up-regulation | Phosphorylation | MAPK14 | hsa1432 |
| Up-regulation | Phosphorylation | MAPK8 | hsa5599 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 | |
| In Vivo Model | HCT116 cells (5×10⁶) in 0.1 mL PBS was inject subcutaneously into the right flank of each mouse. | |||
| Result | These results suggest that the combination treatment with ALT and oxaliplatin may become a potential therapeutic strategy for colon cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS. Int J Biol Sci. 2019 Jun 4;15(8):1676-1684. doi: 10.7150/ijbs.35265. | Click |
