TOP
Nav Bar
  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Alantolactone, Oxaliplatin
Phytochemical Name Alantolactone (PubChem CID: 72724 )
Anticancer drug Name Oxaliplatin (PubChem CID: 9887053 )
Structure of
Phytochemical		 2D-img
Download
2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
Download
2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
Hide/Show
Enhancing Drug Efficacy
Hide/Show
Combination Pair ID: 239
Ref_1
Pair Name Alantolactone, Oxaliplatin
Disease Info [ICD-11: 2B90.Z] Colon cancer Investigative
Biological Phenomena Induction-->ROS accumulation
Gene Regulation Up-regulation Expression ROS1 hsa6098
Up-regulation Phosphorylation MAPK8 hsa5599
Up-regulation Phosphorylation MAPK14 hsa1432
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
RKO Colon carcinoma Homo sapiens (Human) CVCL_0504
In Vivo Model HCT116 cells (5×10⁶) in 0.1 mL PBS was inject subcutaneously into the right flank of each mouse.
Result These results suggest that the combination treatment with ALT and oxaliplatin may become a potential therapeutic strategy for colon cancer.
03. Reference
No. Title Href
1 Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS. Int J Biol Sci. 2019 Jun 4;15(8):1676-1684. doi: 10.7150/ijbs.35265. Click
It has been 465392 visits since 2024.08
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang
TOP